Search results for "α1 acid glycoprotein"

Optical studies on the specific interaction of dipyridamole with alpha 1-acid glycoprotein (orosomucoid).

1982

Abstract The interaction of dipyridamole with α1-acid glycoprotein was investigated by circular dichroism and ultraviolet absorbance measurements as well as by equilibrium dialysis experiments. Dipyridamole is bound to the protein via one site of extremely high affinity and by at least one site of considerably lower affinity. Only the association of dipyridamole with the high affinity site produces typical extrinsic Cotton effects. As a result of experimental observations it is concluded that the high affinity site is located in a hydrophobic protein structure of the glycoprotein.

Binding of several phenothiazine neuroleptics to a common binding site of alpha 1-acid glycoprotein, orosomucoid.

1983

The interaction of several phenothiazine neuroleptics with alpha 1-acid glycoprotein was investigated using circular dichroism and equilibrium dialysis techniques. For chlorpromazine only, one high-affinity binding site of the protein was found. The binding of the drug to this single site generated typical polyphasic extrinsic Cotton effects. Since several other phenothiazine neuroleptics gave qualitatively comparable extrinsic Cotton effects in the presence of alpha 1-acid glycoprotein and potently inhibited the binding of chlorpromazine to the single site, it was concluded that all phenothiazine derivatives investigated bound preferentially to only one common binding site of the alpha 1-a…

Plasmakonzentrationen von Bupivacain bei kontinuierlicher Periduralanästhesie im Kindesalter

1998

Zur postoperativen Schmerztherapie bei Kindern mit Operationen an der unteren Korperhalfte bietet sich eine Periduralanasthesie an. Bisher wurde die initiale Pharmakokinetik bei Kindern untersucht, nicht hingegen der langfristige Verlauf. Ziel dieser Untersuchung war die Erhebung von Daten zum zeitlichen Verlauf des Plasma-Bupivacainspiegels, der sauren α1-Glycoprotein- und Albuminkonzentrationen bei Kindern mit kontinuierlicher Periduralanasthesie in der postoperativen Phase. Methodik:Uber eine 19G Tuohy-Kanule legten wir einen Katheter mit 0,63 mm Ausendurchmesser in den Periduralraum ein. Wahrend der kontinuierlichen periduralen Bupivacaininfusion durfte eine Dosis von 0,4 mg/kgKG/h Bupi…

Psychotropic drug competition for [3H]imipramine binding further indicates the presence of only one high-affinity drug binding site on human α1-acid …

1983